Park Jung-hyun, a former Kodansha editor, was found guilty of murdering his wife, Kanako, in 2019 and sentenced to 11 years in prison.
The Tokyo High Court upheld the previous conviction and sentence, despite Park maintaining his innocence throughout the legal proceedings.
The court dismissed Park's claims of suicide, citing inconsistencies in his story and evidence suggesting strangulation.
Park plans to appeal the latest court decision, but his days in the manga world are likely over as his own sins have caught up with him.